IRS2 and neoplasm: Of the hypoxia signaling, known HIFα-regulated genes include ADM [28], VEGFA [12, 29], PDK3 [30], LOX [31], MXI1 [32], PDK1 [33], XPNPEP1 [34], SLC2A1 [34], IRS2 [35], and PFKFB3 [36], which have been shown to promote tumor growth and progression in various types of cancers.