Considering the rheumatoid arthritis (RA) treatment scenario, which includes disease activity, low-dose prednisone, methotrexate, TNF blockers, IL-6 antagonists, JAK inhibitors, and anti-CD20 therapy, as a prototype for these findings, this study had the main aim of evaluating the risk factors associated with COVID-19 hospitalizations in patients with RA. The gene discussed is TNF; the disease is rheumatoid arthritis.