ATG5 and synovial sarcoma: Previous research demonstrated that the expression of autophagy marker transcription genes and proteins, autophagy-related protein 5 (ATG5) and light chain protein 3B (LC3B) were elevated in tears and conjunctival tissues of SS-DE patients, proposing that autophagy played a role in the pathogenesis of DED and autophagic markers could be used as new diagnostic and therapeutic biomarkers [41], especially the diagnostic ability of ATG5 in tear [42].