CD63 and age-related macular degeneration: One of the main pathogenic factors of AMD was suffering oxidative stress, the expression of vascular endothelial cell growth factor receptor and the release of exosomes were increased, especially exosome-associated marker protein CD63 and lysosome associated membrane glycoprotein 2 increased significantly in stressed RPEs [105], suggesting that exosomes are closely bound up with the occurrence of AMD.