Functional analyses such as dual-luciferase reporter, RNA immunoprecipitation assays, Cell Counting Kit-8, transwell and flow cytometry assay suggested that exosomal circ_0004136 knockdown hampered AML cell viability, cell cycle progression, migration and invasion, and promoted cell apoptosis by targeting the miR570-3p/TSPAN3 axis, highlighting a novel therapeutic strategy for AML management [94]. Here, TSPAN3 is linked to acute myeloid leukemia.