SLC22A12 and obesity due to melanocortin 4 receptor deficiency: An obesity/metabolic syndrome model in mice on a high-fat diet found increased SLC22A12, GLUT9, and ABCG2 expression in the kidney after 8 weeks but not in other transporters [38], while in another study, the expression of SLC22A12 and GLUT9 was measured in mice after a diet rich in fructose, inducing metabolic syndrome and hyperuricemia in the animals, authors reported an increase in the expression of these two genes [39].