A genomic study analyzed the epistasis of ALPK1 with the loci of GLUT9, ALPK1, SLC22A12, and ABCG2, finding a positive predictive value (PPV ≥ 81%) to measure the risk of gout (OR ≥ 12.30) using variants of these genes in different populations. The gene discussed is ALPK1; the disease is gout.