SLC22A12 and hyperuricemia: Although low basal expression of urate transporters such as ABCG2 and SLC22A12 has been reported in peripheral blood of healthy people, we do not know if their leucocyte expression is increased in patients with gout and hyperuricemia and this may show some altered local cellular process; likewise, it is unknown whether these changes in expression are dependent on an inflammatory process or only depend on a hyperuricemic state or both.