In PMNLs of patients, we found a correlation of ALPK1 with CRP, and although there were no significant differences in CRP with controls, the average CRP in patients was high (5.98 ± 4.6 mg/L); however, this increase could indicate a proinflammatory state in some patients, which together with the presence of hyperuricemia favors the recruitment of neutrophils and a new attack of gout. The gene discussed is ALPK1; the disease is hyperuricemia.