ACSL4 and glioblastoma: To determine the mechanism of RND1 in regulating ferroptosis in GBM cells, the expression of several core regulatory proteins of iron metabolism and lipid oxidation were evaluated, including SLC7A11, GPX4, ACSL4, and FTL [6, 19–21], when RND1 was overexpressed or knocked down (Fig. 3A and Additional file 4: Fig. S4A, B).