We observed a strong negative association between the human gene Zinc-Finger Protein 354B (ZFN354B) and three streptococcal genes, sic1 (Q1J9L2), SpyM3_0968 (Q8K763) and MGAS9429_Spy1542 (Q1JK93) in monomicrobial S. pyogenes. We also observed strong associations of S. pyogenes gene SpyM3_0408 (Q7CFC6) with TATA Box-binding protein-associated factor1D (TAF1D) in polymicrobial infections and with mitochondrially encoded NADH dehydrogenase 4L (MT-ND4L) in monomicrobial infections. Here, FLI1 is linked to infection.