Among the top 10 associated SNPs, rs4848627 in GLI2 was found to be associated with development of any KC (OR = 1.53; 95%CI = 1.06–2.13, P = 4.2 × 10–4) and with development of SCCs exclusively (OR = 2.12; 95%CI = 1.39–3.23, P = 3.0 × 10–4) (Table 1).The GLI2 SNP rs4848627 was also in the top SNPs associated with exclusive development of BCCs (OR = 1.38; 95%CI = 1.04–1.83, P = 0.021). This evidence concerns the gene GLI2 and keratoconus.