We have previously shown that peritoneal administration of a peptide mimic of SOCS1, SOCS1-KIR, inhibited progression of experimental autoimmune encephalomyelitis (a rodent model of multiple sclerosis), rescued SOCS1-/- mice from perinatal lethality, and reduced lupus pathologies in preclinical models22–24. The gene discussed is SOCS1; the disease is experimental autoimmune encephalomyelitis.