For instance, in hematological cancers the reactivation of ROR1 signaling in chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and B-cell acute lymphoblastic leukemia (B-ALL) is linked to advanced disease stage and activation of AKT signaling in ROR1-high positive cells [46–48]. Here, AKT1 is linked to mantle cell lymphoma.