PHB1 and neoplasm: Among these proteins are stress-related protein chaperones Hsp90 co-chaperone (CDC37) and DNA J homolog subfamily A member 2 (DNAJA2) [42], DNA repair and replication proteins (RPA1 and RPA2), and prohibitin (PHB), a regulator of ERK signaling and marker of tumor aggressiveness in diffuse large B-cell lymphoma (Fig. 4b) [43, 44].