IRF4 and Miyoshi myopathy: Since this gene was cloned at the breakpoint of a chromosomal translocation, t(6;14)(p25;q32), involving the IgH gene locus in MM cells65, a plethora of in vitro and clinical studies have reported the abnormal overexpression and oncogenic roles of IRF4 in various mature lymphoid neoplasms13–16,18–22,25.