ACE2 and COVID-19: Several SARS-CoV-2 animal models have been developed, including mice expressing human ACE2,78–80 SARS-CoV-2-adaptive mouse,81,82 ferret,83 hamster,84,85 and NHP models.86–88 Although mice can be infected with SARS-CoV-2 by transferring the human ACE2 gene or designing a virus-adapted mouse, no mouse model can simulate all the characteristics of human COVID-19, especially pulmonary vascular disease, hyperinflammatory syndrome, observed in adults and children, respectively.10 The hamster model can simulate serious COVID-19 diseases.