Control (shCTRL) and HMGA1-depleted (shHMGA1) MDA-MB-231 cells were injected subcutaneously into the fat pads of nude mice and, when tumours reached palpable masses (50–100 mm3), mice were treated with paclitaxel three times a week for 5 weeks (Fig. 6A). The gene discussed is HMGA1; the disease is neoplasm.