PMN-MDSC actively communicate with cancer cells through inflammatory mediators and growth factors such as IL8 [122], IL17a [123], CCL2 [124], TNFα [125], BV8, VEGFα [126], and TGFβ plays important roles in various aspects of tumor cell dissemination, invasion, and angiogenesis. This evidence concerns the gene CXCL8 and cancer.