In laryngeal cancer, there was a significant positive association between high NLR values, programmed cell death-ligand 1 (PD-L1) combined positive score <1 (indicating the number of PD-L1 positive cells in relation to total tumor cells), T count rate <30%, and poor outcome highlighting the relationship between circulating immune cells and the TME characteristics [97]. This evidence concerns the gene CD274 and neoplasm.