IL1B and neoplasm: The tumor and mesenchymal cells in the TME express multiple chemokines and cytokines (e.g., CXCL1, CXCL2, CXCL5, CXCL6, IL1, IL1β, IL6, IL8, IL17, TNFα, and G-CSF), which are regulated by KRAS, SNAIL, and NOTCH signaling [45–47].