LAMP3 and neoplasm: Chen et al. found that monocytes were enriched in the M2 state of the bladder tumor region; moreover, a cluster of DCs with high LAMP3 expression was correlated with Treg recruitment, indicating the regulation of immunosuppressive formation.194 Zhang et al. employed scRNA-seq to create the transcriptomic landscape of intrahepatic cholangiocarcinoma and identified six distinct types of fibroblasts.195 The main fibroblast cluster was vascular CAFs, which expressed high levels of IL-6, thereby enhancing the malignancy of the tumor cells.