Based on this database, Ji et al. found that tumor-specific keratinocytes, a subset of keratinocytes in cutaneous squamous cell carcinoma, interact with CAFs, endothelial cells, macrophages, and MDSCs, which influence autocrine and paracrine responses.235 Additional ligands from TAMs and MDSCs to tumor-specific keratinocytes contained ITGA3 and ITGB1, indicating their association with EMT and epithelial tumor invasion. The gene discussed is ITGB1; the disease is neoplasm.