Atlas analysis in HCC classified infiltrating T cells into 11 large subsets.158 Most clusters have been reported in other cancers, such as “pre-exhausted” T cells in NSCLC and breast cancer.134 A unique CD8+ cluster with positive expression of FOXP3 was defined as a Treg-like population and exhibited both suppressive and cell-killing characteristics. Here, CD8A is linked to hepatocellular carcinoma.