CXCL8 was observed primarily during the production of naïve CD4+ cells in the human peripheral blood or in infants.152 Consistent with its function in CD4+ T cells,153 differential gene expression and pathway enrichment analyses suggest that the cluster mediates neutrophil migration and activates MAPK/extracellular signal-regulated kinase pathways, which contribute to tumor growth. The gene discussed is CD4; the disease is neoplasm.