Another study of CRC identified several interactions between tumor cells and myofibroblasts, SPP1+ macrophages, CD8+ T cells, and Treg cells.182 Notably, the connection between IgA+ plasma cells and CD4+ T cells, which supports the mucosal antibody response at the normal site, was weaker than that at the tumor site. Here, SPP1 is linked to colorectal carcinoma.