By analyzing 333 individual DCs and monocytes from metastatic melanoma, Nirschl et al. revealed that homeostatic modules were enriched in monocytes and DCs and were positively correlated with IFN-γ signatures.175 Moreover, SOCS2, a member of the SOCS family that uniquely degrade all other members,176,177 was induced by IFN-γ, which is present on monocytes and part of a tissue signature during melanoma formation. Here, IFNG is linked to melanoma.