Previous studies have revealed that SPP1+ macrophages play a central role in both the pro- and anti-inflammatory phenotype,184–186 which is consistent with the findings of Lee et al. In addition to T cells, Zhang et al. combined 10x genomics and Smart-seq2 to draw a transcriptome landscape of CRC immune cells, focusing on myeloid cells.187 Two distinct TAM populations were identified: C1QC+ and SPP1+ TAM. This evidence concerns the gene SPP1 and colorectal carcinoma.