ABCC5 and posterior cortical atrophy: To analyze the results of screening the GEO database mentioned above and to investigate the role of ABCC5 in drug resistance in vitro, we established two pairs of enzalutamide-resistant and enzalutamide-sensitive PCa cell lines, namely, C4-2BEnza and C4-2BWT, and 22RV1Enza and 22RV1WT, respectively, and evaluated their resistance by determining their IC50 for enzalutamide.