SREBF1 and posterior cortical atrophy: This transcriptional increase in total AR pre-mRNA may be sufficient to increase the mRNA and protein expression of AR-V7 owning a cryptic exon 3 (CE3), which circumvents the enzalutamide-mediated blockage of nuclear translocation of the ligand-receptor complex and activate AR-V7-relied downstream targets, like SREBF1, to maintain the proliferation activity of PCa cells, increases drug resistance [36].