MRGPRF and cancer: To identify novel biomarkers in cutaneous melanoma, we used an integrative bioinformatics analysis, combining our previous identified pan-cancer deregulated genes (DEGs) with web-source available datasets in CM.15 Six shared DEGs were identified, including SVEP1, WIF1, PAMR1, SLIT3, MRGPRF and CCBE1 (Fig. 1a, Supplementary Table S1).