MRGPRF and cancer: We then examined the expression profile of MrgprF in various types of human cancer using GEPIA and CCLE (the cancer cell line encyclopedia) datasets.27,28 Consistent with our previous result,15 MrgprF was found to be unanimously downregulated in multiple human cancerous tissues and cell lines, including cutaneous melanoma, compared to reciprocal controls (Supplementary Fig. S1c, d, Supplementary Table S3–4).