MRGPRD and cancer: For example, MrgprD, was shown to be upregulated in non-small cell lung cancer and the mouse intestinal tract.18–20MRGX2 has been shown to participate in cancer progression after activation by LL-37, a group of antimicrobial peptide gene family cathelicidins.21 These findings indicate that Mrgs play pivotal roles in other normal human developmental processes and pathological conditions, such as human cancers.