Compared with DMBA-treated WT mice, DMBA-treated TG mice showed lower mRNA levels of CD68, a marker of macrophages; Cxcl9, a four-chemokine signature in primary and metastatic PC; [43] and Ccl3, which plays an important role during chronic pancreatitis [44] (Fig. 3B). Here, CCL3 is linked to chronic pancreatitis.