In a study of malnourished Indian adults, in which malnutrition duration and severity were not well defined and there were no well-nourished controls, insulin increase was slow but prolonged in an IVGTT, glucose disposal rate was low and both glucose and insulin responses to arginine infusion were blunted; all responses improved after 2–4 months of nutritional therapy(63). The gene discussed is INS; the disease is nutritional deficiency disease.