RB1 and hepatocellular carcinoma: As shown in Figure 3C–E, the levels of CyclinD1, CyclinE1 and p‐Rb were clearly decreased in HCC cells treated with RR‐171 compared with the NC group and RR‐170 group, while the levels of P21 and p‐P53 were conversely increased in the RR‐171 group.