Our study found that up-expressed hsa-mir-183 and over transcriptional expressions of hsa-mir-183 predicted target genes (ENY2, PLAG1, PDCD6, GNG5, SLC6A6, CELSR3, SLC22A23, SPATS2, CDK5R1, PHF6, MAL2, ATP2C1, NRAS, SLC25A15 and PTDSS1) were observed in BLCA patients. The gene discussed is SPATS2; the disease is bladder transitional cell carcinoma.