At present, the specific signaling pathway that MAL2 participates in bladder cancer is not clear, so we speculate that up-expressed MAL2 may not be the initiating factor of tumorigenesis, but may lead to changes in cell morphology, signal transduction, migration and metabolism by altering protein distribution, thus promoting tumor transformation [38], which is bidirectional. This evidence concerns the gene MAL2 and urinary bladder carcinoma.