Because the three genes, GBP5, DUSP3, and KLF2, are associated with macrophage regulation and other immune pathways [44–46], this gene set may detect a high-risk systemic immune status, provoked by genital or gastrointestinal infection or altered microbiome composition, which could also be differentially associated with LTBI status. The gene discussed is KLF2; the disease is digestive system infectious disorder.