Notably, in this experimental setting characterized by a low tumor burden, mice did not experience sCRS, as indicated by only moderate and reversible weight loss and modest elevation of serum levels of IL-6 and serum amyloid A (SAA), a murine homolog of the human CRS biomarker C-reactive protein (ref. 32 and Supplemental Figure 2, C and D). This evidence concerns the gene IL6 and neoplasm.