By contrast, treatment with BAF312 prevented the tumor-induced increase of NK cells and GrB+ NK cells in the BM (Figure 6, D and E, and Supplemental Figure 11, D and E) but did not affect the frequency of BM Th1 cells (Figure 6F and Supplemental Figure 11F), demonstrating that S1PR5 signaling mediates the egress of NK cells from the gut and their homing to the BM. Here, GZMB is linked to neoplasm.