CD8A and neoplasm: To the best of our knowledge, prior reports on this subject essentially are limited to 2 relevant studies: one study suggests that lymph node sinusoidal CD169+ macrophages in mice could cross-present dead cell–derived tumor Ag to CD8+ T cells, although the efficiency of cross-presentation on a cellular level was not investigated; one other study investigating human CD11c+ ascites macrophages suggested that these cells have a limited capacity to provide costimulatory signals to CD8+ T cells (32, 33).