Detailed analysis of tumor-infiltrating myeloid cells from melanoma patients revealed that the CD206+ Macro_C1QC subset also expressed high levels of HLA-A (MHC I) and CD86, as well as ICOSLG, and low levels of CD274, as we had observed in our cross-presenting CD206+ M2a macrophages (Figure 7, E and F). Here, ICOSLG is linked to neoplasm.