Further corroborating the Ag cross-presenting ability of CD206+ TAM, we have observed a significant positive correlation between MRC1 expression and expression of effector cytotoxic CD8+ T cells markers such as CX3CR1 and Granzyme B (GZMB) in various cancers including cutaneous melanoma, breast carcinoma and colon adenocarcinoma (Supplemental Figure 11). This evidence concerns the gene CD8A and cancer.