CD8A and cutaneous melanoma: The high expression of well-known costimulatory receptors such as ICOSLG and CD86 on CD206+ cross-presenting macrophages is in line with a significant positive correlation between MRC1 and CD8 expression in various human tumors, including skin cutaneous melanoma, colon adenocarcinoma, and breast invasive carcinoma (Supplemental Figure 11, A–C).