GSTM1 and sickle cell disease: Kleen and Zwissler (29) stated that the use of inhalational prostacyclins might be beneficial in specific situations during surgery (e.g., single lung ventilation, lung transplantation, liver transplantation, cardiac surgery, and sickle cell anemia) where modifying Hb-O2 affinity, accompanied by the effect of vasodilation, might ameliorate oxygenation.