SLC5A5 and thyroid tumor: In 1996, N. Carrasco and her team succeeded in cloning of NIS cDNA and thereby provided a new and well-proven dual function tool allowing the establishment of image-guided selective NIS gene transfer into non-thyroidal tumors followed by the application of therapeutically effective radionuclides (Fig. 1)—work that was started by the pioneer study by Shimura et al.