A novel combination of CCNU and TMZ concurrent with RT evaluated in the CeTeG/NOA-09 trial did show improved overall survival in patients with newly diagnosed MGMT-methylated glioblastoma multiforme [3], but since possible downsides regarding effectiveness of lomustine in subsequent recurrence are being discussed, the use of the combination is still limited [123]. The gene discussed is MGMT; the disease is glioblastoma.