In 3 other experiments with lower infection doses (2.4 × 106 CFU, 4.6 × 106 CFU, and 6.2 × 106 CFU), 11 of 13 control mice survived 3 days after infection, while 8 out of 12 of the Trpm5–/– mice died or had to be euthanized during the first 3 days (Figure 8A). Here, TRPM5 is linked to infection.