None of the four SUMO4:c.2T>C variant carriers harbored a hexanucleotide repeat expansion or pathogenic variant in the ALS-associated genes C9orf72 (not analyzed in VALS051), FUS, SOD1, TARDBP, or VCP, or had a family history of ALS. The gene discussed is SUMO4; the disease is amyotrophic lateral sclerosis.