None of the SGLT-2i tested was able to hamper the increase in the mRNA expression of IL-6, IL-8 and IL-1β induced by LPS in THP-1 or by hyperglycaemia in HUVEC (Supplementary Fig. 4), suggesting that these drugs do not have intrinsic anti-inflammatory properties in these settings. The gene discussed is IL6; the disease is Hyperglycemia.