A large number of studies have implicated dysfunctional DNA repair proteins, such as BRCA1, RAD51, FEN1, and Polβ, in BC initiation and progression (Li et al., 2021; Lu et al., 2020; Martin et al., 2007; Thacker, 2005; Wang et al., 2019; Wang et al., 2020b; Xia et al., 2021). The gene discussed is POLB; the disease is breast cancer.