INS and Hyperglycemia: For example, a PubMed search for the predicted transcription repressor ZFP583 retrieved zero results, but a mouse β cell-specific knockout of the chromatin remodeling Swi/Snf proteins BRG1 (SMARCA4) and BRM (SMARCA2) resulted in pancreas hypoplasia, glucose intolerance, hyperglycemia and impaired insulin secretion; in these mice, β-cell Zfp583 gene expression was upregulated 2.75-fold over the WT expression level (Spaeth et al., 2019).