E-cadherin and vimentin are closely associated with epithelial-to-mesenchymal transition, an important process in colon cancer invasion and metastasis characterized by downregulation of epithelial genes, including E-cadherin and zona occludens 1, and upregulation of mesenchymal markers, including N-cadherin and vimentin [26–29]. The gene discussed is VIM; the disease is malignant colon neoplasm.