HMGB1 and Sepsis: Lastly, the DAMPs we note increased, were previously shown to trigger the cytokine storm (e.g., HMGB1; Figure 4I) (Andersson et al., 2020; Hegyi et al., 2020; Yang et al., 2020), cause thrombosis (e.g., extracellular dsDNA, histone-DNA complexes; Figures 4G, 4H and 4J) (Fuchs et al., 2010; Semeraro et al., 2011) and result in a clinical picture of severe sepsis(Xu et al., 2009).