The LA induced increase in coagulation factor III (CFIII; Figure 6A), fibrinogen, plasminogen activation inhibitor-1 (PAI-1), TFPI and soluble PECAM-1/CD31 levels (Figures 6E–6H) are also noted in severe COVID-19 associated thrombosis (Friedrich et al., 2020; Hottz et al., 2020; Li et al., 2021; Lopez-Castaneda et al., 2021; White et al., 2021) as are the thrombocytopenia and an elevated activated clotting time (Figures 6K–6L) (Ackermann et al., 2020; Liu et al., 2020; Terpos et al., 2020). The gene discussed is TFPI; the disease is COVID-19.