HMGB1 and COVID-19: Higher circulating DAMPs (e.g., ds-DNA, HMGB1; Figures 4G–4I), and endothelial proteins such as E-selectin (Figures 4C and 4D), PECAM-1 (Figure 6H), or ICAM-1 (Figures 4E and 4F) provide a mechanistic link for the prothrombotic state and hepatic portal thrombosis, pulmonary thrombosis induced by LA (Figures 6D and 6J), which is similar to COVID-19 autopsies (Diaz et al., 2020; Sonzogni et al., 2020).