The induction of IFN-γ in response to SARS-CoV-2 S1 peptides was impaired in patients with cirrhosis after the 1st (median <10 vs. 79 pg/ml in controls, p <0.001) and 2nd (median 63 vs. 243 pg/ml, p <0.001) vaccination (Fig. 1A). This evidence concerns the gene IFNG and Cirrhosis.