To determine the reactivity of SARS-CoV-2-specific T cells in patients with cirrhosis after COVID-19 vaccination, blood samples collected after the 1st and 2nd vaccine doses were stimulated with multimeric peptides spanning the S1-region of spike 1 followed by analysis of induced levels of T cell-derived IFN-γ. The gene discussed is IFNG; the disease is Cirrhosis.