MAPK8 and early-onset autosomal dominant Alzheimer disease: MAPKs, a family of kinases that also include JNK, have long been implicated in the pathogenesis of AD [77–80], and a recent large-scale proteomic analysis of postmortem AD brain tissue from the Accelerated Medicines Partnership for Alzheimer’s Disease (AMP-AD) Consortium revealed significant enrichment for proteins related to MAPK signaling and metabolism that strongly correlated with cognitive decline [81].