Dysregulation of protein translational machinery, including altered expression of ribosomal proteins, has been observed across multiple Tau transgenic lines, and the aberrant association of Tau with ribosomal proteins, as seen in both MAPT P301L mice and AD brains, has been shown to disrupt synthesis of proteins critical for synaptic function including PSD-95 [51–54]. The gene discussed is DLG4; the disease is Alzheimer disease.