We utilized the Barnes maze behavioral task to probe the learning, spatial memory and executive function in 9-, 12- and 15-month-old TgF344-AD rats, compared to age-matched NTg littermates to assess the potential cognition sequelae of GABAergic remodeling and neurodegeneration in the presence of ongoing Aβ and tau pathology (Fig. 7). The gene discussed is MAPT; the disease is Alzheimer disease.