We quantified hippocampal PHF1+/SST+ neurons at 9, 12 and 15 months of age, and PHF1+/PVB+ neurons at 15-months in TgF344-AD rats, and found significant increases of PHF1+/SST+ neurons over age, and compared to PHF1+/PVB+ neurons at 15 months [overall ANOVA: F(3,8) = 122.0; P < 0.0001; Fig. 4c]. The gene discussed is PHF1; the disease is Alzheimer disease.