MAPT and Alzheimer disease: Overall, the GABAergic neuroplasticity in TgF344-AD rats is beneficial in the short-term in which it supports cognitive resilience; however, it is insufficient in the longer-term under extensive accumulation of Aβ and tau pathology, and robust loss of hippocampal excitatory and inhibitory neurons, ultimately leading to significant impairment in spatial memory, executive function and cognitive flexibility.