RBFOX3 and Alzheimer disease: We thus investigated total neurons in the non-cell layers within the hippocampus and determined a significant increase of neurons immunoreactive for NeuN in TgF344-AD rats compared to NTg (genotype effect: P = 0.02); whereas no age or age × genotype effects were detected (P = 0.65, P = 0.49, respectively; Fig. 2a; Table 2).