In Fig. 6a, seven genes were found to be associated with STK10 directly in the protein–protein interactions analysis, including CEACAM3, ITGAM, TNFRSF1B, ADAM8, ITGB2, SH3BP5 and MS4A3. Mann–Whitney U test was adopted to compare the expression of these genes between normal tissues and tumor samples from AML. The gene discussed is ITGB2; the disease is acute myeloid leukemia.