PARP1 and cancer: Overall, after asbestos exposure, the mutations, polymorphisms, and activation of DNA repair components like XRCC1, ERCC1, PARP, MLH1, MSH2, MSH6, PMS2, RAD50, RAD54L, RAD21, BRCA2, BAP1, and Ku70 are involved in the progression of MMe; because these changes enable cancer cells to repair the damages and escape cell death pathways, leading to MMe development.