In addition, the up-regulation of some RTKs including EGFR, MET, and AXL are observed and introduced as oncogenic components in mesothelioma given these receptors are directly involved in the initiation and activation of pro-survival PI3K/AKT/mTOR signaling pathway, leading to MMe cell viability and survival [23–25]. This evidence concerns the gene MTOR and mesothelioma.