STC2 and colon adenoma: There are several CpG islands in the 5’-flanking region of the upstream sequence relative to STC2 translation start site; the methylation of these CpG islands compromises STC2 expression in cells derived from human ovarian cancer, pancreatic cancer, colon adenoma and leukemia, but not in normal epithelial cells [116]; furthermore, 5-aza-2′-deoxycytidine, a DNA methylation inhibitor successfully induces STC2 expression [116].