BCL2L1 and neoplasm: The conversion of cholesterol to •OH is beneficial to solve the drug resistance, which has cancer cell killing effect, and turn “waste” into “treasure” to maximize drug resistance; and (3) CS shell inhibits the synthesis of the pro-inflammatory enzyme COX, leading to the down-regulation of the anti-apoptotic protein Bcl-XL, thereby increasing the sensitivity of tumor cells to chemotherapeutic drugs.