In our study, clinical pathological tumor types, age, tumor location, histological grade, lymph node metastasis, and molecular phenotype expression (ER, PR, HER-2, Ki-67, CK5/6, E-cad, P63, and P120) for breast cancer patients were compared across the subgroups to discuss in detail the molecular phenotypes and clinical characteristics of CHBC compared to other types of breast cancer. The gene discussed is ESR1; the disease is breast carcinoma.