Generally, any mutation that disrupts the reading frame of dystrophin or induces a premature stop codon results in the loss of functional dystrophin and causes severe DMD, whereas mutations that maintain the dystrophin reading frame typically result in a milder phenotype, known as Becker muscular dystrophy (BMD) [2, 7, 16, 22]. The gene discussed is DMD; the disease is Duchenne muscular dystrophy.