In the SCC samples, LICA (e.g. Treg, CCR, Cytolytic activity, etc.)and TME metabolic functions (e.g. lipid and energy, etc.)were significantly related to ferroptosis genes (e.g. SLC1A5, CD44, NQO1, HMOX1 and STEAP3), and the ferroptosis potential index were also significantly higher than that in the BCC samples. The gene discussed is HMOX1; the disease is skin basal cell carcinoma.