In the SCC samples, LICA (e.g. Treg, CCR, Cytolytic activity, etc.)and TME metabolic functions (e.g. lipid and energy, etc.)were significantly related to ferroptosis genes (e.g. SLC1A5, CD44, NQO1, HMOX1 and STEAP3), and the ferroptosis potential index were also significantly higher than that in the BCC samples. Here, NQO1 is linked to skin basal cell carcinoma.