Their results also presented that the plasma of NAFLD patients induced increased hepatocyte expression of peroxisome-proliferator-activating-ligand-receptor-γ (PPARγ), sterol-regulatory-element-binding-protein-1c (SREBP-1c), nuclear-factor-kappa-light-chain-enhancer of activated B cells (NF-kB), and NADPH oxidase 2 (NOX2), which are implicated to mitochondrial bioenergetic and metabolic signaling [35]. Here, CYBB is linked to metabolic dysfunction-associated steatotic liver disease.