APP and Alzheimer disease: For example, the McGiIll-R-Thys-APP model that harbors the Swedish and Indiana APP mutations (60) and the TgF344-AD model that harbors the Swedish APP mutation along with an exon 9 deletion in the presenilin 1 gene (61) have been used in preclinical PET studies to characterize Aβ pathology progression and neuroinflammation (58, 62–64).