GSX1 and malignant glioma: GSX1 and FOXG1 overexpressed in SHH-1A are known to be predominantly expressed in the cerebral cortex and to have a functional role throughout brain development; SHH1-B tumors showed overexpression of genes linked to neuronal specification (NEUDOD6) [42] but also CACNG3, for which a role in the biology of malignant gliomas has been suggested [44].