In the head and neck squamous cell carcinoma cell line SCC-131, inhibition of p38 significantly reduces tumor spheroid formation and decreases the expression of the CSC markers SOX2, OCT4, KLF4, c-MYC, and CD44, indicating that p38 plays a key role in the maintenance of stemness properties in this cancer type [39]. The gene discussed is POU5F1; the disease is cancer.