We identified 183 LAG3-associated proteins between MESA and FHS, with pathway analysis revealing sixty-four high disease matches in malignancy, autoimmune diseases, neurological disorders, vascular diseases including MI (AKT1, CCL5, CD163, CDH5, CST3, CXCL12, ENG, IL6R, LTA, PF4, PPBP, PSMA6, SELL, TEK, THBS2, TLR4, TNFRSF1A, VCAM1) and heart disease (ANGPT2, CMA1, CST3, CXCL12, DSCAM, ENG, JAG1, NOTCH1, PF4, PPBP, TLR4, TNFRSF1A, TNFRSF1B, VCAM1). The gene discussed is TNFRSF1B; the disease is heart disorder.